Aluminum-induced oxidative stress in lymphocytes of common carp (Cyprinus carpio)

作者：Garcia Medina Sandra; Celene Razo Estrada Amparo; Manuel Gomez Olivan Leobardo; Amaya Chavez Araceli; Madrigal Bujaidar Eduardo; Galar Martinez Marcela^*

来源：Fish Physiology and Biochemistry, 2010, 36(4): 875-882.

DOI：10.1007/s10695-009-9363-1

• Oxidative stress
• Aluminum
• Lymphocytes
• Cyprinus carpio

Several studies of fish have shown that aluminum may induce hypoxia, hypercapnia, metabolic acidosis, and respiratory failure In lymphocytes, morphologic abnormalities and reduced immune activity have been observed Nevertheless, there is little data on oxidative stress and such data are essential in order to identify its mechanism of action The common carp Cyprinus carpio, an omnivorous fish commonly used in commercial aquaculture, has been proposed as a test organism in toxicologic assays due to its economic importance and wide geographic distribution The aim of this work was to evaluate Al-induced oxidative stress in lymphocytes of the common carp C carpio Specimens were exposed to three different concentrations of Al (0 05, 120, and 239 mg/l) in a static exposure system for 96 h At the end of the exposure period, blood was collected and lymphocytes were separated Lipid peroxidation, oxidized protein content and the activity of superoxide dismutase, catalase, and glutathione peroxidase were measured Results show that the tested Al concentrations modified the activity of antioxidant enzymes and elicited higher levels of lipid peroxidation and oxidized proteins The degree of damage induced was concentration and tissue dependent

• 出版日期2010-12