Postnatal hydrocortisone treatment for chronic lung disease in the preterm newborn and long-term neurodevelopmental follow-up

作者：Radernaker K J^*; de Vries L S; Ulterwaal C S P M; Groenendaal F; Grobbee D E; van Bell F

来源：Archives of Disease in Childhood - Fetal and Neonatal Edition, 2008, 93(1): F58-F63.

DOI：10.1136/adc.2007.119545

The benefits versus the risks of postnatal administration of steroids in preterm-born infants are still debatable. This review examines the literature on postnatal hydrocortisone treatment for chronic lung disease (CLD) in preterm-born infants with a particular focus on the effects of such treatment on long-term neurodevelopmental outcomes. Quantitative published evidence does not point to a clear advantage of treatment with hydrocortisone over dexamethasone with regard to the impact on long-term neurological outcomes. However, in the absence of a randomised comparison, a consensus may soon have to be reached on the basis of the best available evidence whether hydrocortisone should replace dexamethasone in the treatment of CLD.

• 出版日期2008-1