Second generation of fucose-based DC-SIGN ligands: affinity improvement and specificity versus Langerin

作者：Andreini Manuel; Doknic Daniela; Sutkeviciute Ieva; Reina Jose J; Duan Janxin; Chabrol Eric; Thepaut Michel; Moroni Elisabetta; Doro Fabio; Belvisi Laura; Weiser Joerg; Rojo Javier; Fieschi Franck^*; Bernardi Anna

来源：Organic and Biomolecular Chemistry, 2011, 9(16): 5778-5786.

DOI：10.1039/c1ob05573a

DC-SIGN and Langerin are two C-type lectins involved in the initial steps of HIV infections: the former acts as a viral attachment factor and facilitates viral invasion of the immune system, the latter has a protective effect. Potential antiviral compounds targeted against DC-SIGN were synthesized using a common fucosylamide anchor. Their DC-SIGN affinity was tested by SPR and found to be similar to that of the natural ligand Lewis-X (Le(X)). The compounds were also found to be selective for DC-SIGN and to interact only weakly with Langerin. These molecules are potentially useful therapeutic tools against sexually transmitted HIV infection.

• 出版日期2011
• 单位中国地震局