Association between Low-Grade Albuminuria and Cardiovascular Risk in Korean Adults: The 2011-2012 Korea National Health and Nutrition Examination Survey

作者：Hong Jae Won; Ku Cheol Ryong; Noh Jung Hyun; Ko Kyung Soo; Rhee Byoung Doo; Kim Dong Jun^*

来源：PLos One, 2015, 10(3): e0118866.

DOI：10.1371/journal.pone.0118866

Background
Recent studies have indicated that low UACR levels (< 30 mu g/mg) previously considered to be in the normal range ('low-grade albuminuria') are associated with cardiovascular morbidity and mortality in the general population.
Methods
We studied 9,736 participants with albuminuria in the normal range from the 2011-2012 Korea National Health and Nutrition Examination Survey (KNHANES).
Results
The weighted prevalences of metabolic syndrome (MS) and the 10-year risk for coronary heart disease measured using the Framingham risk score (FRS) >= 20% (high risk) were 22.5 +/- 0.7% and 14.5 +/- 0.7%, respectively, in males and 23.3 +/- 0.8% and 8.5 +/- 0.4%, respectively in females. Weighted comparisons among the tertiles of UACR revealed that the prevalences of MS and high-risk FRS increased with increasing UACR (MS: males, 15.9 +/- 1.1, 20.2 +/- 1.2, 32.4 +/- 1.5%, respectively; P < 0.001; and females, 17.6 +/- 1.0, 22.7 +/- 1.0, 30.2 +/- 1.4%, respectively; P < 0.001. High-risk FRS: males, 9.5 +/- 0.7, 12.3 +/- 0.9, 22.5 +/- 1.2, respectively; P < 0.001; and females, 5.8 +/- 0.6, 7.9 +/- 0.7, 12.0 +/- 0.9%, respectively; P < 0.001). The positive association persisted after adjusting for hypertension and diabetes. The weighted comparisons among the deciles of UACR revealed that the prevalences of MS and high-risk FRS began to increase at the ranges of 3.89-5.15 and 5.16-7.36 mg/g Cr, respectively.
Conclusion
Low-grade albuminuria was significantly associated with estimated cardiovascular risk and MS in a nationally representative sample of Koreans.

• 出版日期2015-3-5