Development of Sensory Gamma Oscillations and Cross-Frequency Coupling from Childhood to Early Adulthood

作者：Cho Raymond Y^*; Walker Christopher P; Polizzotto Nicola R; Wozny Thomas A; Fissell Catherine; Chen Chi Ming A; Lewis David A

来源：Cerebral Cortex, 2015, 25(6): 1509-1518.

DOI：10.1093/cercor/bht341

• cross-frequency coupling
• development
• GABA
• gamma oscillations
• phase-locking factor
• synaptic pruning

Given the importance of gamma oscillations in normal and disturbed cognition, there has been growing interest in their developmental trajectory. In the current study, age-related changes in sensory cortical gamma were studied using the auditory steady-state response (ASSR), indexing cortical activity entrained to a periodic auditory stimulus. A large sample (n = 188) aged 8-22 years had electroencephalography recording of ASSR during 20-, 30-, and 40-Hz click trains, analyzed for evoked amplitude, phase-locking factor (PLF) and cross-frequency coupling (CFC) with lower frequency oscillations. Both 40-Hz evoked power and PLF increased monotonically from 8 through 16 years, and subsequently decreased toward ages 20-22 years. CFC followed a similar pattern, with strongest age-related modulation of 40-Hz amplitude by the phase of delta oscillations. In contrast, the evoked power, PLF and CFC for the 20- and 30-Hz stimulation were distinct from the 40-Hz condition, with flat or decreasing profiles from childhood to early adulthood. The inverted U-shaped developmental trajectory of gamma oscillations may be consistent with interacting maturational processes-such as increasing fast GABA inhibition that enhances gamma activity and synaptic pruning that decreases gamma activity-that may continue from childhood through to adulthood.

• 出版日期2015-6