Association between obesity and sleep disorders in postmenopausal women

作者：Naufel Maria Fernanda; Frange Cristina; Andersen Monica Levy; Batista Castello Girao Manoel Joao; Tufik Sergio; Ribeiro Eliane Beraldi; Hachul Helena

来源：Menopause-The Journal of the North American Menopause Society, 2018, 25(2): 139-144.

DOI：10.1097/GME.0000000000000962

<jats:title>Abstract</jats:title>
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<jats:title>Objective:</jats:title>
<jats:p>To investigate the relationship between obesity and sleep architecture in postmenopausal women.</jats:p>
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<jats:title>Methods:</jats:title>
<jats:p>One hundred seven postmenopausal women from the Ambulatory of Integrative Treatment for Female Sleep Disorders were invited by telephone to participate in this study. Fifty-three completed the study. We included women aged 50 to 70 years, and excluded women on hormone therapy or missing data. The study consisted of two meetings, including a full-night polysomnography. Menopause status was confirmed by amenorrhea for at least 1 year. Anthropometric measurements included: body mass, height, body mass index (BMI), waist circumference, hip circumference, waist-to-hip ratio (WHR), and neck circumference. Participants were allocated into two groups according to BMI: nonobese group (BMI &lt;30 kg/m<jats:sup>2</jats:sup>) and obese group (BMI ≥30 kg/m<jats:sup>2</jats:sup>).</jats:p>
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<jats:title>Results:</jats:title>
<jats:p>The obese group had significantly (<jats:italic toggle="yes">P</jats:italic> &lt; 0.01) increased values of BMI, neck circumference, waist circumference, and hip circumference. WHR was similar between the groups (<jats:italic toggle="yes">P</jats:italic> = 0.77). Obese participants had significantly increased values of respiratory disturbance index (16.4 vs 9.3 n°/h) and apnea-hypopnea index (14.2 vs 5.6 n°/h). Rapid eye movement sleep latency was positively correlated to body mass (<jats:italic toggle="yes">r</jats:italic> = <jats:italic toggle="yes">P</jats:italic> &lt; 0.01), BMI (<jats:italic toggle="yes">P</jats:italic> &lt; 0.01), and hip circumference (<jats:italic toggle="yes">P</jats:italic> = 0.01). WHR was negatively correlated to sleep efficiency (<jats:italic toggle="yes">P</jats:italic> = 0.03). The linear regression model showed that BMI (<jats:italic toggle="yes">P</jats:italic> &lt; 0.01) and WHR (<jats:italic toggle="yes">P</jats:italic> &lt; 0.01) were positive predictors of rapid eye movement sleep latency.</jats:p>
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<jats:title>Conclusion:</jats:title>
<jats:p>In postmenopausal women, high BMI and abdominal obesity are sources of sleep disturbances, decreasing deep sleep, and sleep efficiency, while increasing the risk of obstructive sleep apnea.</jats:p>
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• 出版日期2018-2