A one-pot, catalyst-free synthesis of novel 2-thioxo-tetrahydropyrimidine derivatives via the three-component reaction of alkyl chloroglyoxalates, alkyl isocyanides, and thioureas

作者：Moradi Loghman^*; Bahrami Chonor; Mirzaei Anvar; Zarehbin Mohammad Rezgar; Yavari Issa

来源：Tetrahedron Letters, 2015, 56(12): 1510-1512.

DOI：10.1016/j.tetlet.2015.02.025

• alpha-Ketoimidoyl chlorides
• Alkyl isocyanides
• 2-Thioxo-tetrahydropyrimidines
• Thiourea
• Acyl chlorides

alpha-Ketoimidoyl chlorides, obtained from the alpha-addition of acyl chlorides to alkyl isocyanides are treated with thiourea derivatives to afford novel 2-thioxo-tetrahydropyrimidine derivatives in good to excellent yields.

• 出版日期2015-3-18