Determining optimal noninvasive parameters for the prediction of left ventricular remodeling in chronic ischemic patients

作者：Rademakers Frank^*; Engvall Jan; Edvardsen Thor; Monaghan Mark; Sicari Rosa; Nagel Eike; Zamorano Jose; Ukkonen Heikki; Ebbers Tino; Di Bello Vitantonio; Voigt Jens Uwe; Herbots Lieven; Claus Piet; D' Hooge Jan

来源：Scandinavian Cardiovascular Journal, 2013, 47(6): 329-334.

DOI：10.3109/14017431.2013.857039

• coronary artery disease
• noninvasive stress imaging
• remodeling

Objectives. DOPPLER-CIP aims to determine the optimal noninvasive parameters (myocardial function, perfusion, ventricular blood flow, cell integrity) and methodology (ergometry, echocardiography, scintigraphy, MRI) in a given ischemic substrate that best predicts the impact of an intervention (or the lack thereof) on adverse morphological ventricular remodeling and functional recovery. Moreover, the relative predictive value of each of these parameters, in respect to the cost of extracting this information in order to enable optimization of cost-effectiveness for improved health care, will be determined by this project. Design. DOPPLER-CIP is a multi-center registry study. All patients with ischemic heart disease included in this study undergo at least two noninvasive stress imaging examinations at baseline. The presence/or absence of left ventricular (LV) remodeling will be assessed after a follow-up of 2 years, during which all cardiac events will be registered. Results. 676 patients were included. Currently, baseline data analysis is almost finished and the follow-up is ongoing. Conclusions. After completion, DOPPLER-CIP will provide evidence-based guidelines toward the most effective use of cardiac imaging in the chronically ischemic heart disease patient. The study will generate information, knowledge, and insight into the new imaging methodologies and into the pathophysiology of chronic ischemic heart disease.

• 出版日期2013-12