Atypical Pituitary Adenoma With Neurocytic Transformation

作者:Rotondo Fabio*; Bernardo Marie Christine F; Scheithauer Bernd W; Latif Shahnila; Bogaev Christopher; Sav Aydin; Kovacs Kalman
来源:Applied Immunohistochemistry & Molecular Morphology, 2014, 22(1): 72-76.
DOI:10.1097/PAI.0b013e3182634969

摘要

Here, we report an example of an atypical prolactin-producing pituitary adenoma showing clear morphologic and immunohistochemical evidence of neurocytic transformation. Its features support the concept that neoplastic neuroendocrine cells, in this case adenohypophyseal cells, are capable of neuronal differentiation and broaden the morphologic spectrum of such rare tumors. Our findings have implications with respect to the nosology of neuronal tumors of the adenohypophysis.