Asymmetric Synthesis of Substituted Homotropinones from N-Sulfinyl beta-Amino Ketone Ketals. (-)-Euphococcinine and (-)-Adaline

作者：Davis Franklin A^*; Edupuganti Ram

来源：Organic Letters, 2010, 12(4): 848-851.

DOI：10.1021/ol902910w

Sulfinimine-derived N-sulfinyl beta-amino ketone ketals on heating with NH(4)OAc:HOAc undergo a four-step intramolecular Mannich cyclization cascade reaction to give homotropinones, such as (-)-euphococcinine, in excellent yields as single isomers.

• 出版日期2010-2-19