A normalised scale for structural genomics target ranking: The OB-Score

作者：Overton Ian M; Barton Geoffrey J^*

来源：FEBS LETTERS, 2006, 580(16): 4005-4009.

DOI：10.1016/j.febslet.2006.06.015

• HTPX
• structural genomics
• target selection
• Pfam
• bioinformatics

Target selection and ranking is fundamental to structural genomics. We present a Z-score scale, the "OB-Score", to rank potential targets by their predicted propensity to produce diffraction-quality crystals. The OB-Score is derived from a matrix of predicted isoelectric point and hydroppobicity values for nonredundant PDB entries solved to <= 3.0 angstrom against a background of UniRef50. A highly significant difference was found between the OB-Scores for TargetDB test datasets. A wide range of OR-Scores was observed across 241 proteomes and within 7868 PfamA families; 73.4% of PfamA families contain >= 1 member with a high OB-Score, presenting favourable candidates for structural studies.

• 出版日期2006-7-10