Multilayer nanoencapsulation: A nanomedicine technology for diabetes research and management

作者：Zhi Zheng Liang; Khan Faaizah; Pickup John C^*

来源：Diabetes Research and Clinical Practice, 2013, 100(2): 162-169.

DOI：10.1016/j.diabres.2012.11.027

• Nanothickness encapsulation
• Glucose sensor
• Fluorescence
• Islet cell transplantation
• Oral insulin
• Diabetes

Nanothickness encapsulation using a layer-by-layer technique has applications in several areas of diabetes research, including improved glucose sensors, islet cell transplantation and oral insulin delivery. We have fabricated microvesicles containing a fluorescence lifetime-based glucose sensing system, with bacterial glucose-binding protein as the glucose receptor. Such sensors are suitable for impregnation in the dermis as a 'smart tattoo' type of non-invasive glucose monitoring technology. Nanoencapsulation of islet cells is intended to alleviate the immediate blood-mediated inflammatory reaction which is responsible for early islet loss post-transplant. In an allogeneic diabetic mouse model, nanoencapsulated islets with phosporylcholine-modified polysaccharide coating, significantly extended survival of transplanted islets. In early studies aimed at formulating an effective oral insulin preparation, insulin-chitosan colloids coated with nanolayers of chitosan and heparin had enhanced acid stability and effectively lowered blood glucose in an animal model.

• 出版日期2013-5