A novel extended-spectrum TEM-type beta-lactamase, TEM-138, from Salmonella enterica serovar infantis

作者:Chouchani Chedly; Berlemont Renaud; Masmoudi Afef; Galleni Moreno; Frere Jean Marie; Belhadj Omrane; Ben Mahrez Kamel*
来源:Antimicrobial Agents and Chemotherapy, 2006, 50(9): 3183-3185.
DOI:10.1128/AAC.00388-06

摘要

A novel natural TEM beta-lactamase with extended-spectrum activity, TEM-138, was identified in a ceftazidime-resistant clinical isolate of Salmonella enterica serovar Infantis. Compared to TEM-1, TEM-138 contains the following mutations: E104K, N1751, and G238S. The bla(TEM-138) gene was located on a 50-kb transferable plasmid. Expression studies with Escherichia coli revealed efficient ceftazidimase and cefotaximase activities for TEM-138.

  • 出版日期2006-9

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