科研之友
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摘要
The mechanism of radiation-induced frank strand break formation in irradiated 5-bromo-2%26apos;-deoxyuridine (BrdU)-labelled DNA is still unclear despite the proven radiosensitizing properties of BrdU. Combination of ESR spectroscopy and quantum chemical modelling points to a simple reaction between the uridine-5-yl radical and water molecules that produces the genotoxic hydroxyl radical.
- 出版日期2014
