A cationic cyclisation route to prenylated indole alkaloids: synthesis of malbrancheamide B and brevianamide B, and progress towards stephacidin A

作者：Frebault Frederic C; Simpkins Nigel S^*

来源：Tetrahedron, 2010, 66(33): 6585-6596.

DOI：10.1016/j.tet.2010.04.093

• Malbrancheamide
• Brevianamide
• Stephacidin
• Diketopiperazine
• Cationic cyclisation

The synthesis of the prenylated indole alkaloids, malbrancheamide B and brevianamide B have been accomplished, starting with a prenylated proline derivative created using the Seebach 'self-reproduction of chirality' method, and using a cationic cascade sequence as the key step to form late-stage bridged diketopiperazine intermediates.

• 出版日期2010-8-14