A Regioselective One-Pot, Three Component Synthesis of 6-Aryl-4-cyano-3(2H)-pyridazinones in Water

作者:Rimaz Mehdi; Khalafy Jabbar*; Moghadam Peyman Najafi
来源:Australian Journal of Chemistry, 2010, 63(9): 1396-1401.
DOI:10.1071/CH09602

摘要

A series of 4-cyano-3(2H)-pyridazinones bearing different aryl substituents in the 6-position of the pyridazinone ring was synthesized regioselectively using a novel efficient one-pot three component reaction of alkyl 2-cyanoacetates with arylglyoxals in the presence of hydrazine hydrate at room temperature in water.

  • 出版日期2010