Dietary vitamin D intake and risk of type 2 diabetes in the European Prospective Investigation into Cancer and Nutrition: the EPIC-InterAct study

作者：Abbas S; Linseisen J^*; Rohrmann S; Beulens J W J; Buijsse B; Amiano P; Ardanaz E; Balkau B; Boeing H; Clavel Chapelon F; Fagherazzi G; Franks P W; Gavrila D; Grioni S; Kaaks R; Key T J; Khaw K T; Kuehn T; Mattiello A; Molina Montes E; Nilsson P M; Overvad K; Quiros J R; Rolandsson O; Sacerdote C; Saieva C; Slimani N; Sluijs I; Spijkerman A M W; Tjonneland A; Tumino R; van der A D L; Zamora Ros R; Sharp S J

来源：European Journal of Clinical Nutrition, 2014, 68(2): 196-202.

DOI：10.1038/ejcn.2013.235

• vitamin D
• type 2 diabetes
• dietary intake
• observational study
• EPIC

BACKGROUND/OBJECTIVES: Prospective cohort studies have indicated that serum vitamin D levels are inversely related to risk of type 2 diabetes. However, such studies cannot determine the source of vitamin D. Therefore, we examined the association of dietary vitamin D intake with incident type 2 diabetes within the European Prospective Investigation into Cancer and Nutrition (EPIC)-InterAct study in a heterogeneous European population including eight countries with large geographical variation.
SUBJECTS/METHODS: Using a case-cohort design, 11 245 incident cases of type 2 diabetes and a representative subcohort (N = 15 798) were included in the analyses. Hazard ratios (HR) and 95% confidence intervals (CIs) for type 2 diabetes were calculated using a Prentice-weighted Cox regression adjusted for potential confounders. Twenty-four-hour diet-recall data from a subsample (N = 2347) were used to calibrate habitual intake data derived from dietary questionnaires.
RESULTS: Median follow-up time was 10.8 years. Dietary vitamin D intake was not significantly associated with the risk of type 2 diabetes. HR and 95% CIs for the highest compared to the lowest quintile of uncalibrated vitamin D intake was 1.09 (0.97-1.22) (P-trend = 0.17). No associations were observed in a sex-specific analysis. The overall pooled effect (HR (95% CI)) using the continuous calibrated variable was 1.00 (0.97-1.03) per increase of 1 mg/day dietary vitamin D.
CONCLUSIONS: This observational study does not support an association between higher dietary vitamin D intake and type 2 diabetes incidence. This result has to be interpreted in light of the limited contribution of dietary vitamin D on the overall vitamin D status of a person.

• 出版日期2014-2