Altered intestinal permeability in patients with relapsing-remitting multiple sclerosis: A pilot study

作者：Buscarinu Maria Chiara; Cerasoli Benedetta; Annibali Viviana; Policano Claudia; Lionetto Luana; Capi Matilde; Mechelli Rosella; Romano Silvia; Fornasiero Arianna; Mattei Gianluca; Piras Eleonora; Angelini Daniela Francesca; Battistini Luca; Simmaco Maurizio; Umeton Renato; Salvetti Marco; Ristori Giovanni

来源：Multiple Sclerosis, 2017, 23(3): 442-446.

DOI：10.1177/1352458516652498

• Biomarkers
• relapsing-remitting
• twins
• intestinal permeability
• gut absorption
• microbiota

Background: Alterations of intestinal permeability (IP) may contribute to the pathophysiology of immune-mediated diseases.
Objective: We investigated the possible association between IP changes and multiple sclerosis (MS).
Methods: We studied 22 patients with relapsing-remitting multiple sclerosis (RRMS) and 18 age- and sex-matched healthy donors (HDs), including five twin pairs (one concordant, and four discordant for disease). Measurement of lactulose (L) and mannitol (M; two non-metabolized sugars) levels in urine samples, after an oral load, allowed to quantify gut dysfunction.
Results: The proportion of participants with increased IP was significantly higher in patients than in HDs (16/22 (73%) versus 5/18 (28%); p=0.001). Accordingly, the L/M urinary ratio showed significantly higher values in patients than in controls (p=0.0284). Urinary mannitol concentration was significantly lower in patients than in controls (p=0.022), suggesting a deficit of absorption from intestinal lumen. Such changes did not appear related to patients' clinical-radiological features.
Conclusion: The relatively high proportion of IP changes in RR-MS patients seems to confirm our work hypothesis and warrants more work to confirm the result on a larger sample, and to understand the implications for related immunological disturbances and intestinal microbiota alterations. Our finding may also have relevance for oral treatments, recently introduced in clinical practice.

• 出版日期2017-3