Dynamic control of cell adhesion on a stiffness-tunable substrate for analyzing the mechanobiology of collective cell migration

作者:Kamimura Masao; Sugawara Michiko; Yamamoto Shota; Yamaguchi Kazuo; Nakanishi Jun
来源:Biomaterials Science, 2016, 4(6): 933-937.
DOI:10.1039/c6bm00100a

摘要

A method was developed for photocontrolling cell adhesion on a gel substrate with defined mechanical properties. Precise patterning of geometrically controlled cell clusters and their migration induction became possible by spatiotemporally controlled photo-irradiation of the substrate. The clusters exhibited unique collective motion that depended on substrate stiffness and cluster geometry.

  • 出版日期2016