A lock-and-key mechanism for the controllable fabrication of DNA origami structures

作者：Rajendran Arivazhagan; Endo Masayuki^*; Hidaka Kumi; Shimada Naohiko; Maruyama Atsushi; Sugiyama Hiroshi

来源：Chemical communications, 2014, 50(63): 8743-8746.

DOI：10.1039/c4cc02244k

Controllable fabrication of DNA origami structures was achieved using cationic comb-type copolymers (CCCs) as locks and polyvinyl sulphonic acid (PVS) as a key. A CCC binds to the phosphate backbone of either M13mp18/staples alone or both together and restricts origami folding, while PVS unlocks the CCC, restoring the formation of origami structures.

• 出版日期2014-8-14