Association between interleukin 1 beta and interleukin 10 concentrations: a cross-sectional study in young adolescents in Taiwan

作者：Chang Jung Su; Chang Chun Chao; Chien Eve Yiwen; Lin Sean S H; Tsai Cheng Shiuan; Bai Chyi Huey; Chao Kuo Ching^*

来源：BMC Pediatrics, 2013, 13(1): 123.

DOI：10.1186/1471-2431-13-123

• IL10
• IL1 beta
• Overweight and obese adolescents
• Taiwan

Background: In adults, low circulating interleukin 10 (IL10) has been associated with obesity and type 2 diabetes. However, studies investigating IL10 in overweight and obese children have yielded conflicting results. The aim of this study was to investigate factors associated with serum IL10 concentration in young Chinese adolescents. %26lt;br%26gt;Methods: Young adolescents (n=325) ages 13.33+/-1.10 years were recruited into the cross-sectional study from 2010 to 2011. Parameters of obesity, individual components of MetS, iron status and serum IL10 were evaluated. %26lt;br%26gt;Results: Compared with their normal weight counterparts, overweight adolescents had lower serum IL10 but higher TNF alpha, nitric oxide (NO) and IL1 beta concentrations (all p%26lt;0.05). Obese adolescents had increased IL1 beta but decreased hepcidin concentration compared with normal weight (p%26lt;0.01 and p%26lt;0.05; respectively). A strong inverse relationship (p%26lt;0.0001) was found between IL10 and pro-inflammatory cytokines (TNF alpha and IL1 beta). Multivariate linear regression analysis showed serum IL1 beta was significantly correlated with IL10 (beta=-0.156, p%26lt;0.0001). When overweight and obese adolescents were assessed separately from normal weight, only IL1 beta was inversely associated with serum IL10 (beta=-0.231, p=0.0009). The association between IL10 and IL1 beta was weaker in adolescents with normal weight (beta=-0.157, p=0.0002), after adjusting for gender, TNF alpha, IFN gamma and NO. %26lt;br%26gt;Conclusions: Our study confirmed that low IL10 concentration is associated with overweight and obesity in young adolescents. We also demonstrated for the first time that pro-inflammatory cytokine IL1 beta is independently associated with IL10. A decline in IL10 concentration in overweight and obese adolescents may further contribute to the IL1 beta-mediated inflammatory environment associated with obesity.

• 出版日期2013-8-14