African ancestry and innate immunity contribute to the incidence of multicentric Castleman%26apos;s disease in HIV-1/Kaposi%26apos;s sarcoma herpesvirus-coinfected individuals

作者：Westrop Samantha J; Lagos Dimitrios; Boshoff Chris; Bower Mark; Imami Nesrina^*

来源：Future Virology, 2012, 7(7): 729-734.

DOI：10.2217/FVL.12.54

• Kaposi%26apos
• s sarcoma herpesvirus
• multicentric Castleman%26apos
• s disease
• single nucleotide polymorphism
• Toll-like receptor 4

Aims: Kaposi%26apos;s sarcoma herpesvirus (KSHV) is the etiological agent of Kaposi%26apos;s sarcoma and multicentric Castleman%26apos;s disease (MCD), a lymphoproliferative disorder associated with high KSHV load. Here, we analyze the frequency of A299G, a TLR4 single nucleotide polymorphism associated with increased MCD incidence, in a cohort of HIV-1(+) individuals, exploring the link between genotype, KSHV disease and ethnicity. Materials %26 methods: One hundred and seven HIV-1(+) patients presenting with KSHV-related (n = 41) and KSHV-unrelated (n = 66) malignancies were analyzed according to ethnicity, and genotyped for A299G. DNA was extracted from peripheral blood, and the presence of A299G determined by pyrosequencing. Results: Of 41 patients presenting with KSHV-related malignancies, 12 were of African ancestry and 29 of European ancestry. MCD was diagnosed in 18 individuals, 50% of whom had African ancestry. HIV-1(+) individuals with KSHV-related malignancies of African ancestry had a 2.4-fold increased occurrence of MCD compared with European counterparts (relative risk: 2.42; 95% Cl: 1.28-4.55; p = 0.025). A299G was found to be present in 33% of black African and 10% of white European patients with KSHV-related malignancies. In the cohort of patients diagnosed with MCD (n = 18), A299G was present at a frequency of 0.33, regardless of ethnicity. Conclusion: The 2.4-fold higher incidence of MCD in patients of African ancestry presenting with KSHV-related malignancies may be due to the more than three-times higher frequency of A299G compared with that observed in European counterparts. This data highlights a clinically relevant consideration for those caring for KSHV+HIV-1(+) patients of African ancestry, linking genetic variation to disease.

• 出版日期2012-7