Negative influence of paternal age on clinical intracytoplasmic sperm injection cycle outcomes in oligozoospermic patients

作者：Ferreira Renata Cristina; de Almeida Ferreira Braga Daniela Paes; de Souza Bonetti Tatiana Carvalho; Pasqualotto Fabio Firmbach; Iaconelli Assumpto Jr; Borges Edson Jr^*

来源：Fertility and Sterility, 2010, 93(6): 1870-1874.

DOI：10.1016/j.fertnstert.2008.12.043

• Paternal age
• ICSI
• implantation
• pregnancy rate

Objective: To evaluate the effect of male age on clinical outcomes of intracytoplasmic sperm injection (ICSI) cycles, according to sperm concentration.
Design: Retrospective, observational study.
Setting: Assisted reproduction center.
Patient(s): The study included 1,024 couples undergoing ICSI cycles with fresh spermatozoa.
Intervention(s): The influence of paternal age on ICSI outcomes of oligozoospermic and normozoospermic patients was evaluated.
Main Outcome Measure(s): Rates of high-quality embryos, pregnancy, implantation, and miscarriage were evaluated through linear logistic regression analyses.
Result(s): When the sperm concentration was abnormal, paternal age influenced implantation (regression coefficient value = -0.7009) and pregnancy rates (odds ratio = 0.95, 95% confidence interval 0.91-0.99). However, in normozoospermic patients, no influence of paternal age was observed on implantation (regression coefficient value = 0.0566) or pregnancy rates (odds ratio = 1.00, 95% confidence interval 0.97-1.03).
Conclusion(s): For couples in which the men are oligozoospermic, the implantation rate could be impaired by increased paternal age. In these couples, the chance of pregnancy decreased 5% for each year of paternal age. When men are normozoospermic, this effect is not observed. (Fertil Steril(R) 2010;93:1870-4.

• 出版日期2010-4