New perspectives on the use of nucleic acids in pharmacological applications: inhibitory action of extracellular self-DNA in biological systems

作者：Mazzoleni Stefano^*; Carteni Fabrizio; Bonanomi Giuliano; Incerti Guido; Chiusano Maria Luisa; Termolino Pasquale; Migliozzi Antonello; Senatore Mauro; Giannino Francesco; Rietkerk Max; Risitano Antonio; Lanzotti Virginia

来源：Phytochemistry Reviews, 2014, 13(4): 937-946.

DOI：10.1007/s11101-014-9386-9

• Drug discovery
• Random screening
• Combinatorial synthesis
• Nucleosides analogues
• Conspecific DNA
• Antisense oligonucleotides
• Autotoxicity

The research for new products against pathogens, parasites and infesting species, in both agriculture and medicine, implies huge and increasing scientific, industrial and economic efforts. Traditional approaches are based on random screening procedures searching for bioactive compounds. However, the success of such methodologies in most cases has been strongly limited by side-effects of the potential new drugs, especially toxicity and pharmacological resistance. The use of nucleic acids in drug development has been introduced searching for target-specific effect. In addition, a recent discovery revealed that randomly fragmented extracellular self-DNA may act as highly species-specific inhibitory product for different species, suggesting an unprecedented use of DNA for biological control. On this base, a new scenario of pharmacological applications is discussed.

• 出版日期2014-12