SOLID-PHASE NUCLEOPHILIC FLUORINATION

作者：Demizu Yosuke; Sano Kaichi; Terayama Naoki; Hakamata Wataru; Sato Yukiko; Inoue Hideshi; Okuda Haruhiro; Kurihara Masaaki^*

来源：Synthetic Communications, 2012, 42(12): 1724-1730.

DOI：10.1080/00397911.2010.535950

• FDG
• fluorination
• microwave
• solid-phase synthesis

This study demonstrates solid-phase nucleophilic fluorination. Polymer-bound 1-phenoxy-2-sulfonyloxyethane, as a model compound, is converted to a fluorinated compound in a short time. Furthermore, this method is applied to synthesize a precursor of 2-deoxy-2-fluoro-D-glucose by solid-phase synthesis using a microwave oven.

• 出版日期2012