A Facile Ionic Liquid Promoted Synthesis, Cholinesterase Inhibitory Activity and Molecular Modeling Study of Novel Highly Functionalized Spiropyrrolidines

作者：Almansour Abdulrahman I; Kumar Raju Suresh^*; Arumugam Natarajan; Basiri Alireza; Kia Yalda; Ali Mohamed Ashraf; Farooq Mehvish; Murugaiyah Vikneswaran

来源：Molecules, 2015, 20(2): 2296-2309.

DOI：10.3390/molecules20022296

A series of novel dimethoxyindanone embedded spiropyrrolidines were synthesized in ionic liquid, [bmim]Br and were evaluated for their inhibitory activities towards cholinesterases. Among the spiropyrrolidines, compound 4f exhibited the most potent activity with an IC50 value of 1.57 mu M against acethylcholinesterase (AChE). Molecular docking simulation for the most active compound was employed with the aim of disclosing its binding mechanism to the active site of AChE receptor.

• 出版日期2015-2