科研之友
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摘要
The region of Xp between DXS7 and the centromere contains the gene for Norrie disease in addition to the genes for several other ophthalmic disorders, A 650-kb YAC containing the loci MAOA, MAOB, and NDP has been used as the starting point for a bidirectional chromosomal walk. A contig of 16 YACs covering between 2 and 3 Mb has been developed in which the following markers/genes are located (in physical order): Xpter - DXS1201 (256ze5) - DXS6668 - DXS228 - DXS77 - DXS7 - MAOA - MAOB - FR12 (pseudogene) - NDP - DXS6670 - RRM2P3 - DXS6671 - DXS742 - Xcen. Seven new STSs are described both for end clones and for internal Alu PCR products from the contig, The contig contains the breakpoint of the t75-2ma-1b (t75) translocation, close to the 5' end of the MAOB gene.
- 出版日期1995-2-10
