A Convenient Method for Cleavage of Amide C-N Bond

作者:Wei Yingfei*; Shi Daxing; Wei Zhen; Xu Juan; Li Jiarong
来源:Chinese Journal of Organic Chemistry, 2012, 32(6): 1126-1130.
DOI:10.6023/cjoc1111023

摘要

A new method for the cleavage of amide C-N bond was studied in this paper. Some factors such as reaction temperature, quantity of CuCl2 and kind of Lewis acid affected the cleavage of amide C-N bond are discussed. And the possible mechanism of C-N bond broken is proposed. This new method possesses lower temperature, less acid and milder conditions.

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