Binding of cGMP to the transducin-activated cGMP phosphodiesterase, PDE6, initiates a large conformational change involved in its deactivation

作者：Yamazaki Akio; Hayashi Fumio; Matsuura Isao; Bondarenko Vladimir A^*

来源：FEBS Journal, 2011, 278(11): 1854-1872.

DOI：10.1111/j.1742-4658.2011.08104.x

• cGMP binding
• cGMP-binding-dependent protein conformational change
• GAF domains
• G-protein-mediated signal transduction
• PDE

Structured digital abstract
<externallink id="http://www.uniprot.org/uniprot/P11541" type="url">PDE6 alpha, <externallink id="http://www.uniprot.org/uniprot/P23439" type="url">PDE6 beta and <externallink id="http://www.uniprot.org/uniprot/P04972" type="url">PDE6 gamma <externallink id="http://www.ebi.ac.uk/ontology-lookup/?termId=MI:0915" type="url">physically interact by <externallink id="http://www.ebi.ac.uk/ontology-lookup/?termId=MI:0071" type="url">molecular sieving (<externallink id="http://mint.bio.uniroma2.it/mint/search/interaction.do?interactionAc=MINT-8146211" type="url">View interaction).

• 出版日期2011-6