科研之友
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摘要
PurposeTo study the feasibility of black-blood contrast in native T-1 mapping for reduction of partial voluming at the blood-myocardium interface. MethodsA saturation pulse prepared heart-rate-independent inversion recovery (SAPPHIRE) T-1 mapping sequence was combined with motion-sensitized driven-equilibrium (MSDE) blood suppression for black-blood T-1 mapping at 3 Tesla. Phantom scans were performed to assess the T-1 time accuracy. In vivo black-blood and conventional SAPPHIRE T-1 mapping was performed in eight healthy subjects and analyzed for T-1 times, precision, and inter- and intraobserver variability. Furthermore, manually drawn regions of interest (ROIs) in all T-1 maps were dilated and eroded to analyze the dependence of septal T-1 times on the ROI thickness. ResultsPhantom results and in vivo myocardial T-1 times show comparable accuracy with black-blood compared to conventional SAPPHIRE (in vivo: black-blood: 1562 56 ms vs. conventional: 1583 +/- 58 ms, P = 0.20); Using black-blood SAPPHIRE precision was significantly lower (standard deviation: 133.9 +/- 24.6 ms vs. 63.1 +/- 6.4 ms, P < .0001), and blood T-1 time measurement was not possible. Significantly increased interobserver interclass correlation coefficient (ICC) (0.996 vs. 0.967, P = 0.011) and similar intraobserver ICC (0.979 vs. 0.939, P = 0.11) was obtained with the black-blood sequence. Conventional SAPPHIRE showed strong dependence on the ROI thickness (R-2 = 0.99). No such trend was observed using the black-blood approach (R-2 = 0.29). ConclusionBlack-blood SAPPHIRE successfully eliminates partial voluming at the blood pool in native myocardial T-1 mapping while providing accurate T-1 times, albeit at a reduced precision. Magn Reson Med 78:484-493, 2017.
- 出版日期2017-8
