Anterior Visual Pathways in Amblyopia: Quantitative Assessment With Diffusion Tensor Imaging

作者：Gumustas Sevtap^*; Altintas Ozgul; Anik Yonca; Kaya Ahmet; Altintas Levent; Inan Nagihan; Ali Demirci

来源：Journal of Pediatric Ophthalmology & Strabismus, 2013, 50(6): 369-374.

DOI：10.3928/01913913-20131125-04

Purpose: To detect the abnormalities of the anterior visual pathways in children with amblyopia with diffusion tensor imaging.
Methods: Ten children with unilateral amblyopia, 5 children with bilateral amblyopia, and 10 control children were treated using diffusion tensor imaging scanning in this institutional practice. Fractional anisotropy and mean diffusivity values were analyzed using diffusion tensor imaging in the prechiasmatic and chiasmatic regions. Fractional anisotropy and mean diffusivity values of the amblyopic groups were compared with the values of the control group using the Kruskal-Wallis test. The Mann-Whitney U test was used to evaluate pairwise differences between groups.
Results: When compared with the control group, prechiasmatic fractional anisotropy values were significantly decreased in both affected and sound fellow eyes in the unilateral amblyopic group (P=.019 and .013), but not in the bilateral amblyopic group (P=.221). Mean diffusivity values were significantly greater in the sound fellow eye in the unilateral amblyopic group in the pre-chiasmatic region (P=.001 and .049).
Conclusion: Diffusion tensor imaging showed a significant decrease in fractional anisotropy and an increase in mean diffusivity values in the unilateral amblyopic group in both affected and sound fellow eyes. These findings may reflect axonal underdevelopment in anterior pathways, particularly in the unilateral amblyopic group.

• 出版日期2013-12