Adhesion molecules in the regulation of CNS myelination

作者：Laursen Li**eth S^*; Ffrench Constant Charles

来源：Neuron Glia Biology, 2007, 3: 367-375.

• oligodendrocyte
• myelin
• axon
• laminin
• integrin
• multiple sclerosis

Myelination is necessary both for rapid salutatory conduction arid the long-term survival of the axon. In the CNS the 17'lyelill sheath isfornied by the oligodendrocytcs. Each oligodendrocytc myelinates several axons and, as the nuiriber of wraps around each axon is determined precisely 1)), the axon dialneter, this requires a close, highly regulated interaction between the axons and each of the oligodendrocyte processes. Adhesion molecules are likely to play a" iniportant role in the bi-directional signalling between axon and oligodcridrocyte that underlies this interaction. Here we review the current knowledge of the function of adhesion molecules in the different phases of oligodendrocyte differentiatio" arid myelination, arid discuss how the properties of these proteins defined by other cell biological systems indicates potential roles in oligodcridrocytcs. We show how thefunction of a number of different adhesion and cell-ccll interaction inolecules such as polysialic acid neural cell adhesion molecule, Lingo-il Notch, neuregulin, integrins and extracellullar inatrix proteins provide negative and positive signals that coordinate the formation of the myclin rnernbranc. Compiling this information front a nuadler of different cell biological and genetic experiments helps its to understand the pathology of multiple sclerosis and direct new areas of research that Inight eventually lead to potential drug targets to increase remyelination.

• 出版日期2007