Allylic C-H Activations Using Cu(II) 2-Quinoxalinol Salen and tert-Butyl Hydroperoxide

作者：Li Yuancheng; Lee Tae Bum; Wang Tanyu; Gamble Audrey V; Gorden Anne E V^*

来源：Journal of Organic Chemistry, 2012, 77(10): 4628-4633.

DOI：10.1021/jo300372q

Using a Cu(II) 2-quinoxalinol salen complex as the catalyst and tert-butyl hydroperoxide (TBHP) as the oxidant, allylic activations of olefin substrates can be converted to the corresponding enones or 1,4-enediones. Excellent yields can be achieved (up to 99%) within a very short reaction time and with great tolerance for additional functional groups. Possible mechanistic pathways have been characterized using Raman spectroscopy, cyclic voltammetry, and theoretical calculations.

• 出版日期2012-5-18