ANATOMICAL AND FUNCTIONAL TESTING IN DIABETIC PATIENTS WITHOUT RETINOPATHY Results of Optical Coherence Tomography Angiography and Visual Acuity Under Varying Contrast and Luminance Conditions

作者：Meshi, Amit; Chen, Kevin C.; You, Qi Sheng; Dans, Kunny; Lin, Tiezhu; Bartsch, Dirk-Uwe; Cheng, Lingyun; Amador-Patarroyo, Manuel J.; Muftuoglu, Ilkay Kilic; Gomez, Maria L.; Nudleman, Eric; Freeman, William R.^*

来源：Retina-The Journal of Retinal and Vitreous Diseases, 2019, 39(10): 2022-2031.

DOI：10.1097/IAE.0000000000002258

• diabetes mellitus
• diabetic retinopathy
• optical coherence tomography angiography
• contrast sensitivity

Purpose: To assess early retinal microvascular and functional changes in diabetic patients without clinical evidence of diabetic retinopathy with optical coherence tomography angiography and central visual analyzer.
Methods: This was an observational case-control study of diabetic patients without diabetic retinopathy and nondiabetic controls. Patients underwent optical coherence tomography angiography imaging and visual acuity testing using the central visual analyzer. The foveal avascular zone area and the capillary density in the superficial and deep capillary plexuses were measured manually by a masked grader.
Results: Sixty eyes from 35 diabetic patients were included in the study group, and 45 eyes from 31 nondiabetic patients were included in the control group. The foveal avascular zone area was not significantly different between the diabetic group and controls (both P > 0.05). The mean capillary density in the deep capillary plexus was significantly lower in diabetic eyes compared with control eyes (P = 0.04). The mean visual acuity in all central visual analyzer modules was significantly decreased in diabetic patients compared with controls (all P < 0.05).
Conclusion: Optical coherence tomography angiography was able to detect retinal microvascular changes in the deep capillary plexus, and the central visual analyzer showed signs of decreased visual acuity under conditions simulating suboptimal contrast and glare in diabetic patients without diabetic retinopathy.

• 出版日期2019-10
• 单位首都医科大学; 北京市眼科研究所