An Efficient Synthesis of Highly Functionalized 4H-Pyrano[3,2-d]isoxazoles via Isocyanide-Based Three-Component Reaction

作者：Esmaeili Abbas Ali^*; Hosseinabadi Rahele; Habibi Azizollah

来源：Synlett, 2010, (10): 1477-1480.

DOI：10.1055/s-0029-1220072

• 4H-pyrano[3,2-d]isoxazole
• isocyanides
• 3-phenylisoxazol-4-(5H)-one
• three-component reactions
• acetylenic esters

We present a novel, convenient, and efficient method for synthesizing polysubstituted 4H-pyrano[3,2-d]isoxazoles based on a three-component reaction. The zwitterions generated from the reaction of isocyanides and dialkyl acetylenedicarboxylates are reacted with 3-phenylisoxazol-4-(5H)-one to produce the title compounds in good yield.

• 出版日期2010-6