Ultra Wide Field Fluorescein Angiography Can Detect Macular Pathology in Central Retinal Vein Occlusion

作者：Tsui Irena^*; Franco Cardenas Valentina; Hubschman Jean Pierre; Yu Fei; Schwartz Steven D

来源：Ophthalmic Surgery, Lasers and Imaging, 2012, 43(3): 257-262.

DOI：10.3928/15428877-20120424-01

The purpose of this study was to evaluate whether ultra wide field fluorescein angiography (UWFFA), a tool established for the detection of peripheral non-perfusion, can also detect macular pathology. A retrospective imaging review was performed on patients with central retinal vein occlusion. UWFFA was graded for angiographic leakage (petalloid and/or diffuse leakage) and presence of abnormalities in the foveal avascular zone and was then correlated to spectral-domain optical coherence tomography (SD-OCT). Sixty-six eyes met inclusion criteria. Intergrader agreement was highly reliable for grading macular leakage on UWFFA ( kappa = 0.75) and moderately reliable for the evaluation of an abnormal foveal avascular zone (kappa = 0.43). Angiographic leakage on UWFFA correlated to macular edema on SD-OCT (P > .0001), and abnormalities in the foveal avascular zone on UWFFA correlated to ganglion cell layer atrophy on SD-OCT (P = .0002). Intergrader reliability in grading UWFFA was better when assessing macular leakage than when assessing macular ischemia. UWFFA findings correlated to macular edema and signs of macular ischemia on SD-OCT. [Ophthalmic Surg Lasers Imaging 2012; 43: 257-262.]

• 出版日期2012-6