ER stress in diffuse large B cell lymphoma: GRP94 is a possible biomarker in germinal center versus activated B-cell type

作者：Boelens Jerina^*; Jais Jean Philippe; Vanhoecke Barbara; Beck Ilse; Van Melckebeke Heleen; Philippe Jan; Bracke Marc; Jardin Fabrice; Briere Josette; Leroy Karen; Offner Fritz; Lust Sofie

来源：Leukemia Research, 2013, 37(1): 3-8.

DOI：10.1016/j.leukres.2012.08.017

• DLBCL
• UPR
• GRP94

The process of B-cell development is characterized by the activation of the unfolded protein response. Under certain circumstances, the unfolded protein response can be manipulated in a cell death-inducing way. Therefore, tackling the unfolded protein response might be an attractive strategy in the treatment of diffuse large B-cell lymphomas. %26lt;br%26gt;Our research showed more basal unfolded protein response activity and differences in the inducibility of ER stress in activated B-cell versus germinal center cell lines. Moreover, the diffuse large B cell lymphoma patient data revealed that the glucose-regulated protein 94 is new potential discriminator for diffuse large B cell lymphoma.

• 出版日期2013-1