Neuronal circuits involving neuropeptide Y in hypothalamic arcuate nucleus-mediated feeding regulation

作者：Kageyama Haruaki; Takenoya Fumiko; Hirako Satoshi; Wada Nobuhiro; Kintaka Yuri; Inoue Shuji; Ota Eiji; Ogawa Tetsuo; Shioda Seiji^*

来源：Neuropeptides, 2012, 46(6): 285-289.

DOI：10.1016/j.npep.2012.09.007

• Neuropeptide
• Immunohistochemistry
• Neuronal interaction

Neuropeptide Y (NPY) is a 36-amino-acid neuropeptide that was first discovered in porcine brain extracts and later in the porcine intestine. It is widely distributed in both the central and peripheral nervous systems and exerts a powerful orexigenic effect. NPY-producing neuronal cell bodies are abundantly localized in the medial arcuate nucleus of the hypothalamus, this being a brain center that integrates signals ,for energy homeostasis. Accumulated evidence shows that hypothalamic neuropeptides such as ghrelin, orexin, melanin-concentrating hormone (MCH), galanin-like peptide (GALP) and proopiomelanocortin (POMC) are involved in the regulation of feeding behavior and energy homeostasis via neuronal circuits in the hypothalamus. NPY also forms part of the feeding-regulating neuronal circuitry in conjunction with other feeding-regulating peptide-containing neurons within the hypothalamus. We summarize here current knowledge of the neuronal interactions between NPY and the different types of feeding-regulating peptide-containing neurons in the hypothalamus based on evidence at the immunohistochemical level and with calcium imaging techniques.

• 出版日期2012-12