Association between polymorphisms in cytokine genes IL-17A and IL-17F and development of allergic rhinitis and comorbid asthma in Chinese subjects

作者：Wang, Min; Zhang, Yuan; Han, Demin^*; Zhang, Luo

来源：Human Immunology, 2012, 73(6): 647-653.

DOI：10.1016/j.humimm.2012.03.010

• TRANSLATIONAL MINIREVIEW SERIES
• GENOME-WIDE ASSOCIATION
• LOWER AIRWAYS
• T(H)17 CELLS
• SUSCEPTIBILITY
• VARIANTS
• HEALTH

Background: Th17 cell lineage, a distinct pro-inflammatory lineage characterized by preferential synthesis of cytokines IL-17A and IL-17F, is thought to play an important role in the pathogenesis of allergic rhinitis (AR). @@@ Objectives: Our aim was to investigate whether polymorphisms in and around IL-17A and IL-17F genes are associated with AR and comorbid asthma. Methods: A case-control comparison was performed in a cohort of 279 AR patients, 197 allergic rhinitis with asthma (AR-A) patients and 281 control Chinese subjects, to investigate associations between 19 tagging single-nucleotide polymorphisms (SNPs) in IL-17A and IL-17F gene regions and manifestation of AR or AR-A. Genotyping was performed using the Sequenom MassARRAY platform. @@@ Results: SNP rs3819024 in IL-17A gene, intergenic SNPs rs1892280 and rs10807439 were specifically associated with AR protective or risk effects, while rs3819024 in IL-17A gene, intergenic SNP rs13192563 in 1L-17F gene were associated with AR-A protective or risk effects. Haplotype analysis showed significant AR risk in haplotype AA (rs1892280G-rs13192563A) and AR protective effect in haplotype GT (rs7758579A-rs119667601); the haplotype AT(rs7758579-rs11966760) were considered AR-A risk. @@@ Conclusions: Our findings preliminarily indicate IL17A and IL17F SNPs, and some intergenic variants have the potential association with AR and comorbid asthma in Chinese population.

• 出版日期2012-6
• 单位首都医科大学; 北京市耳鼻咽喉科研究所