A non-equilibrium thermodynamic model for tumor extracellular matrix with enzymatic degradation

作者：Xue, Shi-Lei; Li, Bo; Feng, Xi-Qiao^*; Gao, Huajian

来源：Journal of the Mechanics and Physics of Solids, 2017, 104: 32-56.

DOI：10.1016/j.jmps.2017.04.002

• Tumor
• Mechanobiology
• Extracellular matrix
• Chemo-mechanical coupling
• Transport
• Enzymatic degradation

The extracellular matrix (ECM) of a solid tumor not only affords scaffolding to support tumor architecture and integrity but also plays an essential role in tumor growth, invasion, metastasis, and therapeutics. In this paper, a non-equilibrium thermodynamic theory is established to study the chemo-mechanical behaviors of tumor ECM, which is modeled as a poroelastic polyelectrolyte consisting of a collagen network and proteoglycans. By using the principle of maximum energy dissipation rate, we deduce a set of governing equations for drug transport and mechanosensitive enzymatic degradation in ECM. The results reveal that osmosis is primarily responsible for the compression resistance of ECM. It is suggested that a well-designed ECM degradation can effectively modify the tumor microenvironment for improved efficiency of cancer therapy. The theoretical predictions show a good agreement with relevant experimental observations. This study aimed to deepen our understanding of tumor ECM may be conducive to novel anticancer strategies.

• 出版日期2017-7
• 单位清华大学