Atypical antipsychotics and suicidal behavior in esquizophrenic or schizo-affective patients

作者：da Rocha Felipe Fliardi^*; Alvarenga Nathalia Bueno; Lage Naira Vassalo; Lanna Trivelato Ana Luiza; Barros Andre Coelho; Correa Humberto

来源：Revista de Psiquiatria Clinica, 2010, 37(5): 228-232.

• Atypical antipsychotic
• clozapine
• esquizophrenia
• schizo-affective disorder
• suicidality

Background The literature concerning the net effect of atypical antipsychotic medication on suicidality is not consistent Objectives The empirical literature relating to the efficacy of pharmacological intervention with atypical antipsychotics in esquizophrenic or schizo-affective patients is comprehensively reviewed Methods: MEDIA NE, LILACS and Cochrane Library were used to search for articles from 1964 to 2009 using these key-words "suicidal behavior" e/ou "suicide" e "atypical antipsychotics" e/ou "antipsychotics" e/ou "clozapine" Results: The strongest and perhaps unique evidence has been shown for clozapine, which seems to have a clinically relevant advantage over other second-generation antipsychotics for reducing suicidality temptation Discussion: Clozapine is the unique medication that modulates suicidal behavior Its action is unknown but is not related do clinical improvement It is the unique drug approved by Food and Drug Administration (FDA) to prevent suicide in esquizophrenic patients but the criteria tor his use is uncertain

• 出版日期2010