摘要

A novel hydrothermal route has been developed to produce metal-chelated magnetic nanobeads which help to study serum peptides profiles by matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrum. The obtained particles were analyzed by TEM, AFM and FT-IR techniques, and it showed that the average particle size ranged between 70-90 nm. It is validated by mass spectrum that the metal-chelated magnetic nanobeads can extract serum peptides in an effective way. These beads are very useful in the clinic studies on serum preparation for mass spectrum in future.