Direct, Regioselective, and Chemoselective Preparation of Novel Boronated Tryptophans by Friedel-Crafts Alkylation

作者:Bartolucci Silvia; Bartoccini Francesca; Righi Marika; Piersanti Giovanni*
来源:Organic Letters, 2012, 14(2): 600-603.
DOI:10.1021/ol203216h

摘要

A facile synthetic approach to the direct preparation of various novel unnatural boronated protected tryptophans using a regio- and chemoselective electrophilic substitution of 4- and 5-boronated indoles with N-protected dehydroalanine is described. The gram-scale synthesis of two free tryptophan boronic acids is also reported.

  • 出版日期2012-1-20