Allylic C-H Amination for the Preparation of syn-1,3-Amino Alcohol Motifs

作者：Rice Grant T; White M Christina^*

来源：Journal of the American Chemical Society, 2009, 131(33): 11707-11711.

DOI：10.1021/ja9054959

A highly selective and general Pd/sulfoxide-catalyzed allylic C-H amination reaction en route to syn-1,3-amino alcohol motifs is reported. Key to achieving this reactivity under mild conditions is the use of electron-deficient N-nosyl carbamate nucleophiles that are thought to promote functionalization by furnishing higher concentrations of anionic species in situ. The reaction is shown to be orthogonal to classical C-C bond-forming/-reduction sequences as well as nitrene-based C-H amination methods.

• 出版日期2009-8-26