A modular design for minor groove binding and recognition of mixed base pair sequences of DNA

作者：Guo Pu; Paul Ananya; Kumar Arvind; Harika Narinder K; Wang Siming; Farahat Abdelbasset A; Boykin David W; Wilson W David

来源：Chemical communications, 2017, 53(75): 10406-10409.

DOI：10.1039/c7cc06246j

The design and synthesis of compounds that target mixed, AT/GC, DNA sequences is described. The design concept connects two N-methyl-benzimidazole-thiophene single GC recognition units with a flexible linker that lets the compound fit the shape and twist of the DNA minor groove while covering a full turn of the double helix.

• 出版日期2017-9-25