Adenosine 5'-monophosphate-activated protein kinase-dependent mTOR pathway is involved in flavokawain B-induced autophagy in thyroid cancer cells

作者：He, Qin; Liu, Wenping; Sha, Sha; Fan, Shanshan; Yu, Yajing; Chen, Li; Dong, Ming^*

来源：CANCER SCIENCE, 2018, 109(8): 2576-2589.

DOI：10.1111/cas.13699

• apoptosis
• autophagy
• flavokawain B
• metabolism
• thyroid cancer

Flavokawain B (FKB), a natural kava chalcone, shows potent antitumor activity in various types of cancer, although the mechanism of action remains unclear. In this study, we report that FKB has profound effects on the metabolic state of human thyroid cancer (TCa) cells, leading to high autophagy flux through upregulation of AMP-activated protein kinase, which in turn inhibits mTOR and activates Beclin-1 in TCa cells. We further report that the autophagy induced by FKB plays a prosurvival role in TCa cells both invitro and invivo. In conclusion, our findings provide evidence that combination treatment with FKB and pharmacological autophagy inhibitors will be a potential therapeutic strategy for the treatment of TCa.

• 出版日期2018-8
• 单位山东大学