Anti-atherosclerotic effects of the glucagon-like peptide-1 (GLP-1) based therapies in patients with type 2 Diabetes Mellitus: A meta-analysis

作者：Song, Xiaoyan; Jia, Hetang; Jiang, Yuebo; Wang, Liang; Zhang, Yan; Mu, Yiming; Liu, Yu^*

来源：Scientific Reports, 2015, 5(1): 10202.

DOI：10.1038/srep10202

• INTIMA-MEDIA THICKNESS
• DIPEPTIDYL PEPTIDASE-4 INHIBITOR
• CARDIOVASCULAR RISK BIOMARKERS
• C-REACTIVE PROTEIN
• ENDOTHELIAL FUNCTION
• JAPANESE PATIENTS
• OXIDATIVE STRESS
• GLYCEMIC CONTROL
• LIRAGLUTIDE
• SITAGLIPTIN

This study assessed the effect of GLP-1 based therapies on atherosclerotic markers in type 2 diabetes patients. 31 studies were selected to obtain data after multiple database searches and following inclusion and exclusion criteria. Age and BMI of the participants of longitudinal studies were 59.8 +/- 8.3 years and 29.2 +/- 5.7 kg/m(2) (Mean +/- SD). Average duration of GLP-1 based therapies was 20.5 weeks. Percent flow-mediated diameter (%FMD) did not change from baseline significantly but when compared to controls, % FMD increased non-significantly following GLP-1-based therapies (1.65 [-0.89, 4.18]; P = 0.2; REM) in longitudinal studies and increased significantly in cross sectional studies (2.58 [1.68, 3.53]; P < 0.00001). Intima media thickness decreased statistically non-significantly by the GLP-1 based therapies. GLP-1 based therapies led to statistically significant reductions in the serum levels of brain natriuretic peptide (-40.16 [-51.50, -28.81]; P < 0.0001; REM), high sensitivity c-reactive protein (-0.27 [-0.48, -0.07]; P = 0.009), plasminogen activator inhibitor-1 (-12.90 [-25.98, 0.18]; P=0.05), total cholesterol (-5.47 [-9.55, -1.39]; P = 0.009), LDL-cholesterol (-3.70 [-7.39, -0.00]; P = 0.05) and triglycerides (-16.44 [-25.64, -7.23]; P = 0.0005) when mean differences with 95% CI in the changes from baselines were meta-analyzed. In conclusion, GLP-1-based therapies appear to provide beneficial effects against atherosclerosis. More randomized data will be required to arrive at conclusive evidence.

• 出版日期2015-6-26
• 单位中国人民解放军总医院; 中国人民解放军第三〇九医院