A useful treatment for patients with advanced mixed-type small cell neuroendocrine carcinoma of the prostate: A case report

作者：Uemura Kei Ichiro^*; Nakagawa Go; Chikui Katsuaki; Moriya Fukuko; Nakiri Makoto; Hayashi Tokumasa; Suekane Shigetaka; Matsuoka Kei

来源：Oncology Letters, 2013, 5(3): 793-796.

DOI：10.3892/ol.2013.1136

• prostatic small cell neuroendocrine carcinoma
• external-beam radiotherapy with intra-arterial chemotherapy
• ischuria
• locally advanced tumor

Treating extended prostatic small cell neuroendocrine carcinoma (PSCNC) is extremely difficult and no standard treatment has yet been established. We experienced a case of advanced mixed-type PSCNC in which the patient achieved long-term survival and local control following combined therapy. Locally advanced PSCNC causing lower urinary obstruction was detected during androgen-ablation therapy for stage D2 mixed adenocarcinoma PSCNC. The patient was treated with intra-arterial infusion chemotherapy using a reservoir system and external-beam radiotherapy (EBRT) to the whole pelvis and local tumor. After chemoradiotherapy, the patient%26apos;s lower urinary obstruction was reduced and did not return during the remaining 40 months of the patient%26apos;s life. The patient survived for 70 months following the start of the androgen-ablation therapy. The present study reports a useful treatment for advanced mixed-type PSCNC, androgen-ablation therapy and chemoradiotherapy. The present results also suggest that the prognostic factors for advanced mixed-type PSCNC are the sensitivity of the conventional adenocarcinoma to androgen-ablation therapy, degree of metastasis and extent of the small cell neuroendocrine carcinoma component.

• 出版日期2013-3