Mullerian Carcinosarcoma Arising in the Cecum Associated With Florid Vascular Proliferation/Glomeruloid Microvascular Proliferation

作者：Stewart Colin J R^*; Abeysuriya Disna; Kumarasinghe Priyanthi; Salfinger Stuart; Tan Jason

来源：International Journal of Gynecological Pathology, 2013, 32(1): 38-43.

DOI：10.1097/PGP.0b013e318257df2a

• Carcinosarcoma
• Florid
• Glomeruloid
• Vascular
• Proliferation

Angiogenesis is required for tumor growth, and the degree of new vessel formation correlates with adverse prognosis in many types of malignancies. It has now been appreciated that tumor-associated vasculature is heterogenous and sometimes includes a complex vasoformative process that has been termed florid vascular proliferation or glomeruloid microvascular proliferation. These vascular lesions are most characteristic of high-grade gliomas and neuroendocrine tumors but are being increasingly recognized in other types of neoplasias as well. Herein we report a case of carcinosarcoma arising within the cecal wall of a 62-yr-old patient that exhibited florid vascular proliferation, particularly at the time of peritoneal recurrence. Recognition of these tumor-associated vasoformative lesions may be important in view of their adverse prognostic association and may become therapeutically relevant considering the current developments in angiogenesis inhibitors.

• 出版日期2013-1