A linker approach to phospholipopeptides

作者：Li Bonan; Liang Jun F^*

来源：European Journal of Lipid Science and Technology, 2016, 118(2): 273-+.

DOI：10.1002/ejlt.201400593

• Conjugation
• Cross-linker
• Lipopeptide
• Liposomes
• Peptides

Peptides and phospholipids are important macromolecules in both the chemistry and biology fields, but phospholipopeptides are barely found in nature and have not been studied. Here, we report a novel and efficient approach to the synthesis of phospholipidpeptides. By utilizing cross-linkers, phospholipopeptides from peptides with varied sequences and lengths were produced from phosphatidylethanolamine at high (>90%) yield, mild conditions and good applied scopes for multiple substrates. Synthetic phospholipopeptides containing bioactive peptide sequences may serve as therapeutics for a wide range of biomedical applications.
Practical applications: Phospholipopeptides are prone to hydrolysis by the endogenous phospholipase activity in cells. Synthetic phospholipopeptides containing a bioactive peptide sequences may serve as therapeutics for a wide range of biomedical applications.

• 出版日期2016-2